Endocrine Abstracts

Hyperprolactinemia is known to have a wide differential with multiple causes including physiological, pathological and pharmacological. Drug induced causes of hyperprolactinemia are myriad however these become significant when prolactin levels rise to proportions that lead to clinical manifestations. We present a case of a 40 years old lady who was referred to endocrinology for an irregular menstrual cycle. Initial investigations revealed a prolactin level of 5767 mIU/l (range...

Traditional literature has dictated diabetes to be a chronic irreversible disease with progression of micro and macrovascular complications. Modern medicine has now started to include bariatric surgery, starch restriction as potential interventions which could control diabetes at initial stages. Our case report is unique as it illustrates patient directed reversal of diabetes with lifestyle intervention. 77 years old gentleman was diagnosed with Type 2 diabetes at the age of 5...

We present an interesting case of Heparin inducedhypoaldosteronism associated hyperkalemia in a 69 year old man with a prosthetic heart valve requiring a right sided nephrectomy for a liposarcoma. His persistent hyperkalaemia failed to respond to conventional treatment initiallybut a switch to Warfarin and use of oral Fludrocortisone was effective in normalisation of observed high renin and low aldosterone levels. Early and timely recognition of Heparin induced hypoaldosteroni...

Gums inflammation (gingivitis) if not treated on time and permitted to grow, ends into periodontitis in which alveolar bone that supports teeth is invaded and destroyed. Juvenile periodontitis is a genetic disorder and can occur without plaque and calculus. It is a disease of people below 30 years of age.Subjects and methods: This cross sectional study involved a total of 160 subjects including 80 chronic periodontitis patients and 80 healthy controls be...

A 67-year-old woman was diagnosed by her GP with hypothyroidism and referred to our department. During the first 2 years after diagnosis, the TSH remained elevated (16–19 mlU/l) with the free T4 ranging 11.1–31.9 pmol/l despite her insistence that compliance with therapy was good and on incremental doses of thyroxine. When seen in the nurse-led thyroid clinic for the first time, concerns were raised to the consultant endocrinologist. Interference with the TSH assay w...

A 54 yr old man presented with a six-month history of palpitations, sweating and weight loss. He had a past history of hypertension, type II diabetes, asthma and was HIV-1 seropositive since 14 yrs and was taking potent anti-retroviral therapy: Nevirapine 200 mg bd; Kaletra 3 capsules bd; and didanosine ec 400 mg od.Investigations confirmed Graves thyrotoxicosis (fT4 72.1 pmol/l; TSH <0.01 mU/l; and TSH receptor antibody positive). He was initially t...

Introduction: More than 95% of cases of Acromegaly are caused by pituitary adenomas that present with insidious onset of symptoms due to local mass effects or due to excess of GH/IGF-1. It is often diagnosed late and results in high morbidity and mortality.Case: We present a case of a woman in her fifties with atypical presentation of acromegaly with a left sided headache for 2 years with no associated visual symptoms an...

Introduction: Secondary hypothyroidism can be a difficult diagnosis to make in patients presenting with fatigue. About 30% of females can develop hypopituitarism post-partum and report symptoms after losing any of the anterior pituitary hormone axis. Central hypopituitarism can occur secondary to various structural and vascular abnormalities but can present with pure hormonal abnormalities.Case: We present a case of a wo...

Glycogen storage disease, which is a metabolic disorderof glycogen storage, affecting 1 in 20000-40000 ive births. This is a case of yound adolescent female with glycogen storage disease type1b, presented with lactic acidosis and managed in ITU.18 years old femae from Honk kong, student in a college, admitted to a dgh hospital with fever, vomiting and abdominal pain for a week. examination showed severe features of dehydratio...

Glycogen storage disease, which is a metabolic disorderof glycogen storage, affecting 1 in 20000-40000 ive births. This is a case of yound adolescent female with glycogen storage disease type1b, presented with lactic acidosis and managed in ITU.18 years old femae from Honk kong, student in a college, admitted to a dgh hospital with fever, vomiting and abdominal pain for a week. examination showed severe features of dehydratio...